A human tRNA methyltransferase 9-like protein prevents tumour growth by regulating LIN9 and HIF1-a
نویسندگان
چکیده
(1) Division of Hematology and Oncology, Department of of Otolaryngology, Tisch Cancer Institute, Mount Sina New York, NY (2) Black Family Stem Cell Institute, Mount Sinai Scho York, NY (3) College of Nanoscale Science and Engineering, Unive University of New York, Albany, NY (4) Department of Biomedical Sciences, School of Public Albany, State University of New York, Albany, NY (5) Department of Chemistry, Massachusetts Instit Cambridge, MA (6) Department of Biological Engineering, Massach Technology, Cambridge, MA (7) Center for Environmental Health Sciences, Massa Technology, Cambridge, MA *Corresponding author: Tel: þ1 518 956-7301; Fax: þ E-mail: [email protected] *Corresponding author: Tel: þ1 212 241 9582; Fax: þ E-mail: [email protected]
منابع مشابه
A human tRNA methyltransferase 9-like protein prevents tumour growth by regulating LIN9 and HIF1-α
Emerging evidence points to aberrant regulation of translation as a driver of cell transformation in cancer. Given the direct control of translation by tRNA modifications, tRNA modifying enzymes may function as regulators of cancer progression. Here, we show that a tRNA methyltransferase 9-like (hTRM9L/KIAA1456) mRNA is down-regulated in breast, bladder, colorectal, cervix and testicular carcin...
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